The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder
Identifieur interne : 000754 ( Main/Exploration ); précédent : 000753; suivant : 000755The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder
Auteurs : Chih-Chun Huang [Taïwan] ; Yun-Hsuan Chang [Taïwan] ; Sheng-Yu Lee [Taïwan] ; Shiou-Lan Chen [Taïwan] ; Shih-Heng Chen [Taïwan] ; Chun-Hsien Chu [Taïwan] ; San-Yuan Huang [Taïwan] ; Nian-Sheng Tzeng [Taïwan] ; I Hui Lee [Taïwan] ; Tzung Lieh Yeh [Taïwan] ; Yen Kuang Yang [Taïwan] ; Ru-Band Lu [Taïwan]Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2012-07.
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- KwdEn :
Abstract
Bipolar I (BP‐I) and bipolar II (BP‐II) disorders are the two most common subtypes of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP‐I and BP‐II groups, for which the underlying etiology differentiating these two subtypes remains unclear. The genetic association between both subtypes is essential for improving our understanding. The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1), one of the dopaminergic pathways, as well as the brain‐derived neurotrophic factor (BDNF) gene, were reported as candidate genes in the etiology of bipolar disorder. Therefore, we examined the contribution of the BDNF and DRD2/ANKK1 genes and their interaction to the differentiation of BP‐I and BP‐II. Seven hundred ninety‐two participants were recruited: 208 with BP‐I, 329 with BP‐II, and 255 healthy controls. The genotypes of the BDNF and DRD2/ANKK1 Taq1A polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. A significant main effect for the Val/Val genotype of the BDNF Val66Met polymorphism predicted BP‐II patients. The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP‐II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP‐II disorder and that BP‐I and BP‐II are genetically distinct. © 2012 Wiley Periodicals, Inc.
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DOI: 10.1002/ajmg.b.32055
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xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Sheng U" sort="Lee, Sheng U" uniqKey="Lee S" first="Sheng-Yu" last="Lee">Sheng-Yu Lee</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Psychiatry, National Cheng Kung University Hospital, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Shiou An" sort="Chen, Shiou An" uniqKey="Chen S" first="Shiou-Lan" last="Chen">Shiou-Lan 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Lee</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Psychiatry, National Cheng Kung University Hospital, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Yeh, Tzung Lieh" sort="Yeh, Tzung Lieh" uniqKey="Yeh T" first="Tzung Lieh" last="Yeh">Tzung Lieh Yeh</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Psychiatry, National Cheng Kung University Hospital, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Psychiatry, College of Medicine, National 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Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Addiction Research Center, College of Medicine, 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J. Med. Genet.</title><idno type="ISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-07">2012-07</date><biblScope unit="volume">159B</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="501">501</biblScope><biblScope unit="page" to="507">507</biblScope></imprint><idno type="ISSN">1552-4841</idno></series><idno type="istex">E2C426AC2BB5BE540D1289D17BD413DCE77FD504</idno><idno type="DOI">10.1002/ajmg.b.32055</idno><idno type="ArticleID">AJMG32055</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4841</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>BDNF</term><term>DRD2/ANKK1</term><term>bipolar disorders</term><term>genetic interaction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bipolar I (BP‐I) and bipolar II (BP‐II) disorders are the two most common subtypes of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP‐I and BP‐II groups, for which the underlying etiology differentiating these two subtypes remains unclear. The genetic association between both subtypes is essential for improving our understanding. The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1), one of the dopaminergic pathways, as well as the brain‐derived neurotrophic factor (BDNF) gene, were reported as candidate genes in the etiology of bipolar disorder. Therefore, we examined the contribution of the BDNF and DRD2/ANKK1 genes and their interaction to the differentiation of BP‐I and BP‐II. Seven hundred ninety‐two participants were recruited: 208 with BP‐I, 329 with BP‐II, and 255 healthy controls. The genotypes of the BDNF and DRD2/ANKK1 Taq1A polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. A significant main effect for the Val/Val genotype of the BDNF Val66Met polymorphism predicted BP‐II patients. The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP‐II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP‐II disorder and that BP‐I and BP‐II are genetically distinct. © 2012 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Huang, Chih Hun" sort="Huang, Chih Hun" uniqKey="Huang C" first="Chih-Chun" last="Huang">Chih-Chun Huang</name></noRegion><name sortKey="Chang, Yun Suan" sort="Chang, Yun Suan" uniqKey="Chang Y" first="Yun-Hsuan" last="Chang">Yun-Hsuan Chang</name><name sortKey="Chang, Yun Suan" sort="Chang, Yun Suan" uniqKey="Chang Y" first="Yun-Hsuan" last="Chang">Yun-Hsuan Chang</name><name sortKey="Chen, Shih Eng" sort="Chen, Shih Eng" uniqKey="Chen S" first="Shih-Heng" last="Chen">Shih-Heng Chen</name><name sortKey="Chen, Shiou An" sort="Chen, Shiou An" uniqKey="Chen S" first="Shiou-Lan" last="Chen">Shiou-Lan Chen</name><name sortKey="Chu, Chun Sien" sort="Chu, Chun Sien" uniqKey="Chu C" first="Chun-Hsien" last="Chu">Chun-Hsien Chu</name><name sortKey="Huang, Chih Hun" sort="Huang, Chih Hun" uniqKey="Huang C" first="Chih-Chun" last="Huang">Chih-Chun Huang</name><name sortKey="Huang, San Uan" sort="Huang, San Uan" uniqKey="Huang S" first="San-Yuan" last="Huang">San-Yuan Huang</name><name sortKey="Lee, I Hui" sort="Lee, I Hui" uniqKey="Lee I" first="I Hui" last="Lee">I Hui Lee</name><name sortKey="Lee, I Hui" sort="Lee, I Hui" uniqKey="Lee I" first="I Hui" last="Lee">I Hui Lee</name><name sortKey="Lee, Sheng U" sort="Lee, Sheng U" uniqKey="Lee S" first="Sheng-Yu" last="Lee">Sheng-Yu Lee</name><name sortKey="Lee, Sheng U" sort="Lee, Sheng U" uniqKey="Lee S" first="Sheng-Yu" last="Lee">Sheng-Yu Lee</name><name sortKey="Lu, Ru And" sort="Lu, Ru And" uniqKey="Lu R" first="Ru-Band" last="Lu">Ru-Band Lu</name><name sortKey="Lu, Ru And" sort="Lu, Ru And" uniqKey="Lu R" first="Ru-Band" last="Lu">Ru-Band Lu</name><name sortKey="Lu, Ru And" sort="Lu, Ru And" uniqKey="Lu R" first="Ru-Band" last="Lu">Ru-Band Lu</name><name sortKey="Lu, Ru And" sort="Lu, Ru And" uniqKey="Lu R" first="Ru-Band" last="Lu">Ru-Band Lu</name><name sortKey="Lu, Ru And" sort="Lu, Ru And" uniqKey="Lu R" first="Ru-Band" last="Lu">Ru-Band Lu</name><name sortKey="Lu, Ru And" sort="Lu, Ru And" uniqKey="Lu R" first="Ru-Band" last="Lu">Ru-Band Lu</name><name sortKey="Lu, Ru And" sort="Lu, Ru And" uniqKey="Lu R" first="Ru-Band" last="Lu">Ru-Band Lu</name><name sortKey="Tzeng, Nian Heng" sort="Tzeng, Nian Heng" uniqKey="Tzeng N" first="Nian-Sheng" last="Tzeng">Nian-Sheng Tzeng</name><name sortKey="Yang, Yen Kuang" sort="Yang, Yen Kuang" uniqKey="Yang Y" first="Yen Kuang" last="Yang">Yen Kuang Yang</name><name sortKey="Yang, Yen Kuang" sort="Yang, Yen Kuang" uniqKey="Yang Y" first="Yen Kuang" last="Yang">Yen Kuang Yang</name><name sortKey="Yang, Yen Kuang" sort="Yang, Yen Kuang" uniqKey="Yang Y" first="Yen Kuang" last="Yang">Yen Kuang Yang</name><name sortKey="Yang, Yen Kuang" sort="Yang, Yen Kuang" uniqKey="Yang Y" first="Yen Kuang" last="Yang">Yen Kuang Yang</name><name sortKey="Yeh, Tzung Lieh" sort="Yeh, Tzung Lieh" uniqKey="Yeh T" first="Tzung Lieh" last="Yeh">Tzung Lieh Yeh</name><name sortKey="Yeh, Tzung Lieh" sort="Yeh, Tzung Lieh" uniqKey="Yeh T" first="Tzung Lieh" last="Yeh">Tzung Lieh Yeh</name><name sortKey="Yeh, Tzung Lieh" sort="Yeh, Tzung Lieh" uniqKey="Yeh T" first="Tzung Lieh" last="Yeh">Tzung Lieh Yeh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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